Modeling Neuroimmune Interactions in Human Subjects and Animal Models to Predict Subtype Specific Multidrug Treatments for Gulf War Illness

Gulf War Illness (GWI) is a persistent chronic neuroinflammatory illness exacerbated by external stressors and characterized by fatigue, musculoskeletal pain, cognitive and neurological problems linked to underlying immunological dysfunction for which there is no known treatment. Here, we constructed a logic model of immune regulatory behavior between human clinical samples and mouse models of GWI subtyped by exposure to traumatic stress. We identify several ideal multi-intervention strategies and potential drug candidates that may be used to treat chronic neuroinflammation in GWI.