Patent AT-E401085-T1: [Translated] METHODS OF PROTECTION AGAINST GENOTOXIC MUtagenesis

A method for protecting against mutational damage in mammalian cells induced by irradiation comprising administering a phosphorothioate or phosphorothiate metabolite selected from the group consisting S-2-(3-aminopropylamino)ethylphosphorothioic acid, S-1-(aminoethyl) phosphorothioic acid, S-Ä2-(3-methylaminopropyl) aminoethylÜ phosphorothioate acid, S-2-(4-aminobu-lamino) ethylphosphorothioic acid, 3-Ä(2-mercaptoethyl) aminoÜ propionamide p-toluenesulfonate, S-1-(2-hydroxy-3-amino) propyl phosphorothioic acid, 2-Ä3-(methylamino) propylaminoÜ ethanethiol, 2-(aminopropylamino)ethanethiol, S-2-(5-aminopentylamino) ethyl phosphorothioic acid, 1 Ä3-(3-(aminopropyl) thiazolidin-2-Y1Ü-D-gluco-1,2,3,4,5 pentanepentol dihydrochloride and N,N'-(dithiodi-2,1-ethanediyl)bis-1,3-propanediamme to the mammal before or up to 3 hours after irradiation.