Patent AT-E401397-T1: [Translated] DIRECTED EVOLUTION OF BIOMOLECULES USING MICROSTRUCTURES

Selection (M1) of genotype variants from libraries in a micro-structure comprising feeding a test fluid (102) containing a genotype library in an expressible form and with suitable expression aids into a micro-structure together with a barrier fluid (101) to form separate compartments (109,111) in the test fluid, is new. An assay fluid (103) can be added to the test fluid compartments in (M1). The compartments are carried through the micro-structure to give an expression of the genotype in the phenotype in the compartments, for the phenotypes to be detected. The compartments are selected according to their detected phenotypes.