Patent AT-E401576-T1: [Translated] USE OF A NUCLEAR-RESTRICTED PROTEIN FOR THE DIAGNOSIS AND THERAPY OF ALZHEIMER'S DISEASE AND RELATED DEEP NEURODEGENERATION DISORDERS

The present invention discloses the differential expression of the gene coding for the nuclear restricted protein/brain, NRP/B, in specific brain regions of Alzheimer's disease patients. Based on this finding this invention provides a method for diagnosing or prognosticating a neurodegenerative disease, in particular Alzheimer's disease, in a subject, or for determining whether a subject is at increased risk of developing such a disease. Furthermore, this invention provides therapeutic and prophylactic methods for treating or preventing Alzheimer's disease and related neurodegenerative disorders using a gene coding for a nuclear restricted protein, in particular the nuclear restricted protein/brain, NRP/B. A method of screening for modulating agents of neurodegenerative diseases is also disclosed.