TheTnfrh1(Tnfrsf23) gene is weakly imprinted in several organs and expressed at the trophoblast-decidua interface

TheTnfrh1gene (gene symbolTnfrsf23) is located near one end of a megabase-scale imprinted region on mouse distal chromosome 7, about 350 kb distant from the nearest known imprinting control element. Within 20 kb ofTnfrh1is a related gene calledTnfrh2(Tnfrsf22) These duplicated genes encode putative decoy receptors in the tumor necrosis factor (TNF) receptor family. Although other genes in this chromosomal region show conserved synteny with genes on human Chr11p15.5, there are no obvious human orthologues ofTnfrh1orTnfrh2.