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BLAST (Basic Local Alignment Search Tool) finds regions of similarity between biological sequences. BLAST includes several specialized search interfaces: SmartBLAST, Primer-BLAST, Global Align, CD-Search, IgBLAST,…
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Provides an overview of the C++ language with a focus on its use in accessing resources of the National Center for Biotechnology Information at the National Library of Medicine, National Institutes of Health.
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GRAF (Genetic Relationship and Fingerprinting) is a C++ program that quickly finds the closely related subjects, infers subject ancestry, determines subject sexes using genotypes and compares the results derived from…
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E-utilities (Entrez Programming Utilities) are a set of eight server-side programs that provide a stable interface into the Entrez query and database system at the National Center for Biotechnology Information (NCBI).
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A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
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Identifies the conserved domains present in a protein sequence. CD-Search uses RPS-BLAST (Reverse Position-Specific BLAST) to compare a query sequence against position-specific score matrices that have been prepared…
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The BioSample database contains descriptions of biological source materials used in experimental assays.
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A database that contains sequences built from the existing primary sequence data in GenBank. The sequences and corresponding annotations are experimentally supported and have been published in a peer-reviewed scientific…
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Conserved Domain Database (CDD) is a protein annotation resource that consists of a collection of well-annotated multiple sequence alignment models for ancient domains and full-length proteins.
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IgBLAST was developed at NCBI to facilitate analysis of immunoglobulin as well as T cell receptor (TR) sequences. It uses BLAST search algorithm.
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The BioProject database links to data that have been or will be deposited into archival databases maintained at members of the International Nucleotide Sequence Database Consortium (INSDC, which comprises the DNA…
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Users can display, sort, subset and download position-specific score matrices (PSSMs) either from CDD records or from Position Specific Iterated (PSI)-BLAST protein searches.
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UniVec and UniVec_Core databases in FASTA format.
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Whole Genome Shotgun (WGS) projects are genome assemblies of incomplete genomes or incomplete chromosomes of prokaryotes or eukaryotes that are generally being sequenced by a whole genome shotgun strategy. WGS projects…
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An automated analytical system for producing organized views of the transcriptome from a growing number of organisms. UniGene was retired in July 2019; however, you will continue to be able to access archived data.
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Three dimensional structures provide a wealth of information on the biological function and the evolutionary history of macromolecules. They can be used to examine sequence-structure-function relationships,…
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NCBI creates a variety of educational products including courses, workshops, webinars, training materials and documentation. NCBI educational events are free and open to everyone. All NCBI educational materials are…