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BLAST (Basic Local Alignment Search Tool) finds regions of similarity between biological sequences. BLAST includes several specialized search interfaces: SmartBLAST, Primer-BLAST, Global Align, CD-Search, IgBLAST,…
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GRAF (Genetic Relationship and Fingerprinting) is a C++ program that quickly finds the closely related subjects, infers subject ancestry, determines subject sexes using genotypes and compares the results derived from…
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A stand-alone application for viewing 3-dimensional structures from NCBI Entrez retrieval service. Runs on Windows, Macintosh, and UNIX and can be configured to receive data from most popular Web browsers.
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Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific…
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A public domain quality assurance software package that facilitates the assessment of multiplex short tandem repeat (STR) DNA profiles based on laboratory-specific protocols.
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E-utilities (Entrez Programming Utilities) are a set of eight server-side programs that provide a stable interface into the Entrez query and database system at the National Center for Biotechnology Information (NCBI).
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A utility for computing alignment of proteins to genomic nucleotide sequence based on a variation of the Needleman Wunsch global alignment algorithm and specifically accounts for introns and splice signals.
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Identifies the conserved domains present in a protein sequence. CD-Search uses RPS-BLAST (Reverse Position-Specific BLAST) to compare a query sequence against position-specific score matrices that have been prepared…
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CDTree is a stand-alone application for classifying protein sequences and investigating their evolutionary relationships. CDTree can import, analyze and update existing Conserved Domain (CDD) records and hierarchies,…
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GEO (Gene Expression Omnibus) is a public functional genomics data repository supporting MIAME-compliant data submissions. There are also tools provided to help users query and download experiments and curated gene…
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A computer algorithm that identifies similar protein 3-dimensional structures. Structure neighbors for every structure in MMDB are pre-computed and accessible via links on the MMDB Structure Summary pages.
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Supports finding human phenotype/genotype relationships with queries by phenotype, chromosome location, gene, and SNP identifiers. Currently includes information from dbGaP, the National Human Genome Research Institute…
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Information about retroviruses and specialized tools for the analysis of retroviral proteins and genomes. The tools on this page aid in the identification, study and analysis of retroviral genomes and proteins. For…
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Database of Genomic Structural Variation (dbVar) is NCBI's database of human genomic Structural Variation — large variants >50 bp including insertions, deletions, duplications, inversions, mobile elements,…
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Quickly identifying segments of a nucleic acid sequence that may be of vector origin.
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This site is for browsing WGS (Whole Genome Shotgun) genomes, TSA (Transcriptome Shotgun Assemblies) and TLS (Targeted Locus Study) sets. WGS sequences are incomplete genomes that have been sequenced by a whole genome…
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LinkOut is a service that allows you to link directly from PubMed and other NCBI databases to a wide range of information and services beyond the NCBI systems. LinkOut aims to facilitate access to relevant online…
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A collection of Reference Sequence (RefSeq) proteins, from the complete genomes of prokaryotes, plasmids, and organelles, that have been grouped and annotated based on sequence similarity and protein function.
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Database of Genotype and Phenotype (dbGaP) was developed to archive and distribute the data and results from studies that have investigated the interaction of genotype and phenotype in Humans.
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IgBLAST was developed at NCBI to facilitate analysis of immunoglobulin as well as T cell receptor (TR) sequences. It uses BLAST search algorithm.