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Background Pseudomonas aeruginosa and Burkholderia cepacia infections of cystic fibrosis patients' lungs are often resistant to conventional antibiotic therapy. Protegrins are antimicrobial peptides with potent activity…
Updated Oct 29, 2026
HealthData.Gov
Background Postal surveys are a popular instrument for studies about continuing medical education habits. But little is known about the accuracy of responses in such surveys. The objective of this study was to quantify…
Updated Oct 29, 2026
HealthData.Gov
Background Antibody-directed enzyme prodrug therapy (ADEPT) is a promising new approach to deliver anticancer drugs selectively to tumor cells. In this approach, an enzyme is conjugated to a tumor-specific antibody. The…
Updated Oct 29, 2026
HealthData.Gov
Background The greater susceptibility of children to renal injury in post-diarrheal hemolytic-uremic syndrome (HUS) may be related, at least in part, to heightened renal cell sensitivity to the cytotoxic effect of Shiga…
Updated Oct 29, 2026
HealthData.Gov
Objective: To determine the frequency and prognosis of the various causes of low systemic vascular resistance (SVR). Design: Analysis of consecutive patients over a 5-year period; retrospective review. Setting: Medical…
Updated Oct 29, 2026
HealthData.Gov
Growth factors mediate tissue interactions and regulate a variety of cellular functions that are critical for normal lung development and homeostasis. Besides their involvement in lung pattern formation, growth and cell…
Updated Oct 29, 2026
HealthData.Gov
Background To better understand the molecular interactions of Bt toxins with non-target insects, we have examined the real-time binding specificity and affinity of Cry1 toxins to native silkworm (Bombyx mori) midgut…
Updated Oct 29, 2026
HealthData.Gov
Aim To demonstrate the effects of combined inhaled nitric oxide and surfactant replacement as treatment for acute respiratory distress syndrome. This treatment has not previously been documented for reperfusion injury…
Updated Oct 29, 2026
HealthData.Gov
Background The impact factors of scientific journals are interesting but not unproblematic. It is speculated that the number of journals in which citations can be made correlates with the impact factors in any given…
Updated Oct 29, 2026
HealthData.Gov
The demand for intensive care has increased relentlessly over the past 30 years. It is now regarded as a necessity rather than a luxury. The provision of intensive care has lagged behind that demand. Thus, patients who…
Updated Oct 29, 2026
HealthData.Gov
Background Reversible protein phosphorylation is relatively unexplored in the intracellular protozoa of the Apicomplexa family that includes the genus Plasmodium, to which belong the causative agents of malaria. Members…
Updated Oct 29, 2026
HealthData.Gov
Background The relative efficacy of antiemetics for the treatment of postoperative nausea and vomiting (PONV) is poorly understood. Methods Systematic search (MEDLINE, Embase, Cochrane Library, bibliographies, any…
Updated Oct 29, 2026
HealthData.Gov
Equipment review: A color-coded system to facilitate specimen collection and storage in a multicenter trial
Updated Oct 29, 2026
HealthData.Gov
Background Morphological and electrophysiological studies of ischemic muscles in peripheral arterial disease disclosed evidence of denervation and fibre atrophy. The purpose of the present study is to describe…
Updated Oct 29, 2026
HealthData.Gov
Many alarms, as they now exist in most monitoring systems, are not usually perceived as helpful by the medical staff because of the high incidence of false alarms. This paper gives an overview of the problems related to…
Updated Oct 29, 2026
HealthData.Gov
Background The evaluation of randomized trials for cancer screening involves special statistical considerations not found in therapeutic trials. Although some of these issues have been discussed previously, we present…
Updated Oct 29, 2026
HealthData.Gov
Background The development and activation of CD4+ helper T cell (Th) subsets with distinct patterns of unbalanced production of cytokines play an important part in infectious, allergic and autoimmune diseases. Human…
Updated Oct 29, 2026
HealthData.Gov
The hedgehog signalling pathway has been implicated in many different processes in fly and vertebrate development. It is now known that the hedgehog cascade is crucial for the patterning of the early respiratory system.…
Updated Oct 29, 2026
HealthData.Gov
Background A study was undertaken to resolve preliminary conflicting results on the proliferation of leukemia cells observed with different c-myc antisense oligonucleotides. Results RNase H-active, chimeric…
Updated Oct 29, 2026
HealthData.Gov
Background Some pathogenic bacteria are genetically very homogeneous, making strain discrimination difficult. In the last few years, tandem repeats have been increasingly recognized as markers of choice for genotyping a…
Updated Oct 29, 2026
