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Background Blood leukocytes constitute two interchangeable sub-populations, the marginated and circulating pools. These two sub-compartments are found in normal conditions and are potentially affected by non-normal…
Updated Oct 29, 2026
HealthData.Gov
Background Because cells progressing to cancer must proliferate, marker proteins specific to proliferating cells may permit detection of premalignant lesions. Here we compared the sensitivities of a classic…
Updated Oct 29, 2026
HealthData.Gov
Background Modern drug discovery is concerned with identification and validation of novel protein targets from among the 30,000 genes or more postulated to be present in the human genome. While protein-protein…
Updated Oct 29, 2026
HealthData.Gov
Background We previously showed that systemic administration of the atypical neuroleptic clozapine in the rat altered a number of urodynamic variables and inhibited the external urethral sphincter. Since clozapine acts…
Updated Oct 29, 2026
HealthData.Gov
Background Disruption of the balance between apoptosis and proliferation is considered to be an important factor in the development and progression of tumours. In the present study we determined the in vivo cell…
Updated Oct 29, 2026
HealthData.Gov
Several recent meta-analyses have shown that the use of SDD can reduce the occurrence of nosocomial pneumonia among ventilated patients in the intensive care unit (ICU) setting. However, the use of SDD has also been…
Updated Oct 29, 2026
HealthData.Gov
Background Circulating levels of tumor necrosis factor (TNF) and lymphotoxin-α (LT-α) have been associated with outcome in solid and hematologic malignancies. Within the TNF gene and the LT-α gene, polymorphisms have…
Updated Oct 29, 2026
HealthData.Gov
This conference was the third in a series focusing on developments in the therapy of rheumatoid arthritis (RA) and other rheumatic conditions with biologicals; in many ways, it was perhaps the best one so far. One…
Updated Oct 29, 2026
HealthData.Gov
The pathogenesis of systemic vasculitis is complex and is likely to involve many mechanisms. There is a growing body of evidence that T cells may contribute to the pathogenesis of anti-neutrophil cytoplasmic antibody…
Updated Oct 29, 2026
HealthData.Gov
Inhibitors of the 3-hydroxy-3-methylglutaryl coenzyme A reductase enzyme have recently been shown to stimulate bone formation in rodents both in vitro and in vivo. In bone cells, these inhibitors increase the gene…
Updated Oct 29, 2026
HealthData.Gov
Background Reproductive systems of male moths contain circadian clocks, which time the release of sperm bundles from the testis to the upper vas deferens (UVD) and their subsequent transfer from the UVD to the seminal…
Updated Oct 29, 2026
HealthData.Gov
Background In most organisms proper reductional chromosome segregation during meiosis I is strongly correlated with the presence of crossover recombination structures (chiasmata); recombination deficient mutants lack…
Updated Oct 29, 2026
HealthData.Gov
Gene therapy in rheumatoid arthritis: how to target joint destruction?
Updated Oct 29, 2026
HealthData.Gov
Some provocative thoughts on damage and repair of DNA
Updated Oct 29, 2026
HealthData.Gov
Background Several lines of evidence strongly suggest that agouti-related peptide (AGRP) plays a key role in the regulation of metabolic function but ablation of the AGRP gene has no apparent effect on metabolic…
Updated Oct 29, 2026
HealthData.Gov
The influence of HLA DRB1 alleles on B-cell homeostasis was analyzed in 164 patients with rheumatoid arthritis (RA). The percentages of CD19+ B lymphocytes determined in the peripheral circulation of 94 retrospectively…
Updated Oct 29, 2026
HealthData.Gov
After activation CD4+ helper T cells differentiate into T-helper (Th) 1 or Th2 effector cells. These two subsets are characterized by their distinct cytokine expression pattern and the immune function they mediate. Over…
Updated Oct 29, 2026
HealthData.Gov
Informed consent and research design in critical care medicine
Updated Oct 29, 2026
HealthData.Gov
Background: Hyperbilirubinaemia is a common occurrence in patients who are admitted to intensive care units (ICUs) after major surgery, and it is associated with high mortality. We investigated the incidence of…
Updated Oct 29, 2026
HealthData.Gov
Background Gene expression profiling among different tissues is of paramount interest in various areas of biomedical research. We have developed a novel method (DADA, Digital Analysis of cDNA Abundance), that calculates…
Updated Oct 29, 2026
