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Background Icodextrin is a high molecular weight, starch-derived glucose polymer, which is capable of inducing sustained ultrafiltration over prolonged (12–16 hour) peritoneal dialysis (PD) dwells. The aim of this study…
Updated Oct 29, 2026
HealthData.Gov
Background In the Confidential Enquiry into Maternal Deaths (CEMD) Report, the very high risk of mortality in women who refuse blood transfusions is highlighted. The objectives were to establish current knowledge about,…
Updated Oct 29, 2026
HealthData.Gov
Background The genome of invertebrates is rich in retroelements which are structurally reminiscent of the retroviruses of vertebrates. Those containing three open reading frames (ORFs), including an env-like gene, may…
Updated Oct 29, 2026
HealthData.Gov
The role of X-chromosome inactivation in female predispositionto autoimmunity
Updated Oct 29, 2026
HealthData.Gov
Focusing on diffuse (interstitial) lung disease: a rapidly evolving field
Updated Oct 29, 2026
HealthData.Gov
Background An A54T polymorphism at the fatty acid binding protein 2 (FABP2) locus was found to be associated with insulin resistance in non-diabetic Pima Indians. To see whether this association is present in other…
Updated Oct 29, 2026
HealthData.Gov
Background Brain death is strictly defined medically and legally. This diagnosis depends on three cardinal neurological features: coma, absent brainstem reflexes, and apnea. The diagnosis can only be made, however, in…
Updated Oct 29, 2026
HealthData.Gov
Muscle relaxants in intensive care unit (ICU) patients are predominantly administered to facilitate intubation. The adverse effect profile of succinylcholine is such that its use in the ICU must be considered obsolete.…
Updated Oct 29, 2026
HealthData.Gov
CD8+ T cells dominate the lymphocyte population in synovial fluid in chronic inflammatory arthritis. It is known that these CD8+ T cells are often clonally or oligoclonally expanded, but their specificity and their…
Updated Oct 29, 2026
HealthData.Gov
Background Many members of the public have poor mental health literacy. A Mental Health First Aid training course was developed in order to improve this. This paper describes the training course and reports an…
Updated Oct 29, 2026
HealthData.Gov
Background 5-fluorouracil remains the standard therapy for patients with advanced/metastatic colorectal cancer. Pre-clinical studies have demonstrated the biological modulation of 5-fluorouracil by methotrexate and…
Updated Oct 29, 2026
HealthData.Gov
Background Intensivists must provide enough analgesia and sedation to ensure dying patients receive good palliative care. However, if it is perceived that too much is given, they risk prosecution for committing…
Updated Oct 29, 2026
HealthData.Gov
Background Practice guidelines have been developed in response to the observation that variations exist in clinical medicine that are not related to variations in the clinical presentation and severity of the disease.…
Updated Oct 29, 2026
HealthData.Gov
Background Little is known about genetic factors affecting intraocular pressure (IOP) in mice and other mammals. The purpose of this study was to determine the IOPs of genetically distinct mouse strains, assess the…
Updated Oct 29, 2026
HealthData.Gov
Destruction of cartilage and bone are hallmarks of human rheumatoid arthritis (RA), and controlling these erosive processes is the most challenging objective in the treatment of RA. Systemic interleukin-4 treatment of…
Updated Oct 29, 2026
HealthData.Gov
The recent scientific session of the American College of Cardiology (ACC), held in Orlando, provided a forum for ongoing cardiovascular clinical trials from around the world. The high point was clearly the first ever…
Updated Oct 29, 2026
HealthData.Gov
Evidence for a role of diet in asthma and chronic obstructive pulmonary disease (COPD) has been accumulating rapidly over the past decade. Associations have been reported between the intake of fruit, fish, antioxidant…
Updated Oct 29, 2026
HealthData.Gov
Background Infections pose a substantial burden to the health of older adults. In this report, we describe the proceedings of a workshop to formulate and prioritize research questions about infections in older adults…
Updated Oct 29, 2026
HealthData.Gov
Background Luteinizing hormone secreted by the anterior pituitary gland regulates gonadal function. Luteinizing hormone secretion is regulated both by alterations in gonadotrope responsiveness to hypothalamic…
Updated Oct 29, 2026
HealthData.Gov
Background Several neuromuscular blocking (NMB) agents are available for clinical use in anesthesia. The present study was performed in order to identify preferences and behaviors of anesthesiologists for using…
Updated Oct 29, 2026
