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To assess the impact of somatic hypermutation and selective influences on the Vλ light chain repertoire in systemic lupus erythematosus (SLE), the frequency and pattern of mutations were analyzed in individual CD19+ B…
Updated Oct 29, 2026
HealthData.Gov
Background Genetic screens in Drosophila have provided a wealth of information about a variety of cellular and developmental processes. It is now possible to screen for mutant phenotypes in virtually any cell at any…
Updated Oct 29, 2026
HealthData.Gov
Background This study was designed to evaluate if erythropoietin (EPO) is effective in the treatment of cancer related anemia, and if its effect remains unchanged when data are analyzed according to various clinical and…
Updated Oct 29, 2026
HealthData.Gov
Background The yeast yCCR4 factor belongs to the CCR4-NOT transcriptional regulatory complex, in which it interacts, through its leucine-rich repeat (LRR) motif with yPOP2. Recently, yCCR4 was shown to be a component of…
Updated Oct 29, 2026
HealthData.Gov
Background In previous experiments, it was demonstrated that maternal antibodies (maAb) against rabies in foxes (Vulpes vulpes) were transferred from the vixen to her offspring. However, data was lacking from cubs…
Updated Oct 29, 2026
HealthData.Gov
Background Nasopharyngeal carcinoma (NPC) is a rare tumor in most parts of the world but occurs at relatively high frequency among people of Chinese descent. The cytochrome P450 2E1 enzyme (CYP2E1) is responsible for…
Updated Oct 29, 2026
HealthData.Gov
The abundance and activation of macrophages in the inflamed synovial membrane/pannus significantly correlates with the severity of rheumatoid arthritis (RA). Although unlikely to be the 'initiators' of RA (if not as…
Updated Oct 29, 2026
HealthData.Gov
The evaluation of yeast derivatives as adjuvant of the immune response to the Bm86 antigen in cattle: Correction
Updated Oct 29, 2026
HealthData.Gov
Background We present a simple method to train a potential function for the protein folding problem which, even though trained using a small number of proteins, is able to place a significantly large number of native…
Updated Oct 29, 2026
HealthData.Gov
At times of crisis when epidemics rage and begin to take their toll on affected populations, as we have been witnessing with African trypanosomiasis in subSahara, the dichotomy of basic versus applied research deepens.…
Updated Oct 29, 2026
HealthData.Gov
Pharmacology of the critically ill
Updated Oct 29, 2026
HealthData.Gov
Analysis of subgroup results in a clinical trial is surprisingly unreliable, even in a large trial. This is the result of a combination of reduced statistical power, increased variance and the play of chance. Reliance…
Updated Oct 29, 2026
HealthData.Gov
Background: Abdominal compartment syndrome is defined as the adverse physiologic effects of increased intra-abdominal pressure. Prolonged, unrelieved pressure may lead to respiratory compromise, renal impairment,…
Updated Oct 29, 2026
HealthData.Gov
Background Detection of changes in a protein's evolutionary rate may reveal cases of change in that protein's function. We developed and implemented a simple relative rates test in an attempt to assess the rate…
Updated Oct 29, 2026
HealthData.Gov
Epidemiological studies have established that fenfluramine, D-fenfluramine, and aminorex, but not other appetite suppressants, increase the risk of primary pulmonary hypertension (PH). One current hypothesis suggests…
Updated Oct 29, 2026
HealthData.Gov
Case reports suggest that solvents are associated with various connective tissue diseases (systemic sclerosis, scleroderma, undifferentiated connective tissue disease, systemic lupus erythematosis, and rheumatoid…
Updated Oct 29, 2026
HealthData.Gov
Relative mRNA levels from maize organs have been quantified by hybridization to maize arrays fabricated with 5,376 unique expressed sequence tag clones. mRNAs from embryos, three vegetative organs (leaf blades, leaf…
Updated Oct 29, 2026
HealthData.Gov
Stress hyperglycemia and diabetes mellitus with myocardial infarction are associated with increased risk for in-hospital mortality, congestive heart failure, or cardiogenic shock. Hyperglycemia triggers free radical…
Updated Oct 29, 2026
HealthData.Gov
A decade ago, we reviewed the field of clinical ethics; assessed its progress in research, education, and ethics committees and consultation; and made predictions about the future of the field. In this article, we…
Updated Oct 29, 2026
HealthData.Gov
Introduction Prone positioning in respiratory failure has been shown to be a useful adjunct in the treatment of severe hypoxia. However, the prone position can result in dislodgment or malfunction of tubes and cannulae.…
Updated Oct 29, 2026
