A design prototype by Datopian, not an official website
Find a Commonwealth ResourceHealthData.Gov
Background In order to compare the effectiveness of different antipsychotic drugs in the treatment of schizophrenia it is very important to evaluate subjective response and compliance in patient cohorts treated…
Updated Oct 29, 2026
HealthData.Gov
Background One of the signatures of Alzheimer's disease is the accumulation of aggregated amyloid protein, Aβ, in the brain. Aβ arises from cleavage of the Amyloid Precursor protein by β and γ secretases, which present…
Updated Oct 29, 2026
HealthData.Gov
Background Animal and organ culture experiments have shown beneficial inhibitory estrogen effects on post injury neointima development. The purpose of this study was to investigate whether such estrogen effects are…
Updated Oct 29, 2026
HealthData.Gov
Immunological mechanisms participate in the pathogenesis of human chronic inflammatory periodontal disease (CIPD). Human CD4+ lymphocytes express functionally heterogeneous profiles of cytokine production. CD26 is an…
Updated Oct 29, 2026
HealthData.Gov
Background Antibiotic-resistant bacteria such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococcus (VRE, are an increasing problem world-wide, causing intractable wound infections.…
Updated Oct 29, 2026
HealthData.Gov
Reactive antigenic epitopes on presumed autoantigens of biologic interest have been examined by many researchers. The central third complementarity-determining region (CDR3) residues of a human monoclonal…
Updated Oct 29, 2026
HealthData.Gov
Background Oceans are iron-deficient and nutrient-poor environments. These conditions impart limitations on our understanding of and our ability to identify microorganisms from the marine environment. However, less of…
Updated Oct 29, 2026
HealthData.Gov
Background Soluble guanylyl cyclase (sGC) is the main receptor for nitric oxide (NO) when the latter is produced at low concentrations. This enzyme exists mainly as a heterodimer consisting of one α and one β subunit…
Updated Oct 29, 2026
HealthData.Gov
Background In vitro maturation of mammalian oocytes is an area of great interest due to its potential application in the treatment of infertility. The morphological and physiological changes that occur during oocyte…
Updated Oct 29, 2026
HealthData.Gov
Background Thioredoxin reductase (TR) is a redox active protein involved in many cellular processes as part of the thioredoxin system. Presently there are three recognised forms of mammalian thioredoxin reductase…
Updated Oct 29, 2026
HealthData.Gov
November's Institute of Medicine (IOM) report on medical errors has sparked debate among US health policy makers as to the appropriate response to the problem. Proposals range from the implementation of nationwide…
Updated Oct 29, 2026
HealthData.Gov
Background Angiotensin converting enzyme inhibitors are routinely prescribed to patients with chronic kidney disease because of their known renoprotective effects. We evaluated the effect of short-term therapy with the…
Updated Oct 29, 2026
HealthData.Gov
Background It is possible that psychopathological differences exist between the restricting and bulimic forms of anorexia nervosa. We investigated localized differences of brain blood flow of anorexia nervosa patients…
Updated Oct 29, 2026
HealthData.Gov
Managing death in the intensive care unit: bringing back the humanity
Updated Oct 29, 2026
HealthData.Gov
Background The p16INK4A gene product halts cell proliferation by preventing phosphorylation of the Rb protein. The p16INK4a gene is often deleted in human glioblastoma multiforme, contributing to unchecked Rb…
Updated Oct 29, 2026
HealthData.Gov
Background The existence of a prenuclear abduction paresis is still debated. Methods In a retrospective design, we identified 22 patients with isolated unilateral (n = 20) or bilateral (n = 2) abduction paresis and…
Updated Oct 29, 2026
HealthData.Gov
Proteomics technologies enable profiling of autoantibody responses using biological fluids derived from patients with autoimmune disease. They provide a powerful tool to characterize autoreactive B-cell responses in…
Updated Oct 29, 2026
HealthData.Gov
Background We thoroughly analyse the results of 40 blind predictions for which an experimental answer was made available at the fourth meeting on the critical assessment of protein structure methods (CASP4). Using our…
Updated Oct 29, 2026
HealthData.Gov
Background There is debate concerning methods for calculating numbers needed to treat (NNT) from results of systematic reviews. Methods We investigate the susceptibility to bias for alternative methods for calculating…
Updated Oct 29, 2026
HealthData.Gov
We have investigated the thermal stability of the Fusarium solani pisi cutinase as a function of pH, in the range from pH 2–12. Its highest enzymatic activity coincides with the pH-range at which it displays its highest…
Updated Oct 29, 2026
