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Background Transcriptional transactivation is a process with remarkable tolerance for sequence diversity and structural geometry. In studies of the features that constitute transactivating functions, acidity has…
Updated Oct 29, 2026
HealthData.Gov
Background Depending on their larval environment, female honeybees develop into either queens or workers. As in other polyphenisms, this developmental switch depends not on genomic differences between queens and workers…
Updated Oct 29, 2026
HealthData.Gov
Background: Sodium bicarbonate cotransporter (NBC) genes encode proteins that execute coupled Na+ and HCO3- transport across epithelial cell membranes. We report the discovery, characterization, and genomic context of a…
Updated Oct 29, 2026
HealthData.Gov
Background Nitrogen fixation gene expression in Sinorhizobium meliloti, the alfalfa symbiont, depends on a cascade of regulation that involves both positive and negative control. On top of the cascade, the two-component…
Updated Oct 29, 2026
HealthData.Gov
Background We have used commercially available cDNA arrays to identify EphB4 as a gene that is up-regulated in colon cancer tissue when compared with matched normal tissue from the same patient. Results Quantitative…
Updated Oct 29, 2026
HealthData.Gov
Background The power of DNA microarrays derives from their ability to monitor the expression levels of many genes in parallel. One of the limitations of such powerful analytical tools is the inability to detect certain…
Updated Oct 29, 2026
HealthData.Gov
Background: Homeotic genes are key developmental regulators that are highly conserved throughout evolution. Their encoded homeoproteins function as transcription factors to control a wide range of developmental…
Updated Oct 29, 2026
HealthData.Gov
Background SAGE (serial analysis of gene expression) is a recently developed technique for systematic analysis of eukaryotic transcriptomes. The most critical step in the SAGE method is large scale amplification of…
Updated Oct 29, 2026
HealthData.Gov
Background Members of the ribonuclease III superfamily of double-stranded(ds)-RNA-specific endoribonucleases participate in diverse RNA maturation and decay pathways in eukaryotic and prokaryotic cells. A human RNase…
Updated Oct 29, 2026
HealthData.Gov
The lack of efficient techniques for assessing the biological implications of microarray gene-expression data remains an important obstacle in exploiting this information. To address this need, a mining technique has…
Updated Oct 29, 2026
HealthData.Gov
Background Methods for extracting useful information from the datasets produced by microarray experiments are at present of much interest. Here we present new methods for finding gene sets that are well suited for…
Updated Oct 29, 2026
HealthData.Gov
Background: Classic methods of identifying genes involved in neural function include the laborious process of behavioral screening of mutagenized flies and then rescreening candidate lines for pleiotropic effects due to…
Updated Oct 29, 2026
HealthData.Gov
Background Inhalation of Ascaris suum antigen by allergic monkeys causes an immediate bronchoconstriction and delayed allergic reaction, including a pulmonary inflammatory infiltrate. To identify genes involved in this…
Updated Oct 29, 2026
HealthData.Gov
Background Current methodology often cannot distinguish second primary breast cancers from multifocal disease, a potentially important distinction for clinical management. In the present study we evaluated the use of…
Updated Oct 29, 2026
HealthData.Gov
Background Gene expression is affected by population density. Cell density is a potent negative regulator of cell cycle time during exponential growth. Here, we asked whether SV40 large T antigen (Tag) levels, driven by…
Updated Oct 29, 2026
HealthData.Gov
A robust semi-parametric normalization technique has been developed, based on the assumption that the large majority of genes will not have their relative expression levels changed from one treatment group to the next,…
Updated Oct 29, 2026
HealthData.Gov
Genomics, or the study of genes and their function, is a burgeoning field with many new technologies. In the present review, we explore the application of genomic approaches to the study of pulmonary hypertension (PH).…
Updated Oct 29, 2026
