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During our careers, we have developed new and innovative concepts pertaining to the pathophysiology of osteoarthritis which have assisted in the development of new therapeutic approaches. Moreover, our laboratory has…
Updated Oct 29, 2026
HealthData.Gov
Background Bone morphogenetic proteins (BMPs) and transforming growth factor-βs (TGF-βs) are important regulators of bone repair and regeneration. BMP-2 and TGF-β1 have been shown to inhibit gap junctional intercellular…
Updated Oct 29, 2026
HealthData.Gov
Background Several Trichoderma strains have been reported to be effective in controlling plant diseases, and the action of fungal hydrolytic enzymes has been considered as the main mechanism involved in the antagonistic…
Updated Oct 29, 2026
HealthData.Gov
Background Chemical methods of transfection that have proven successful with cell lines often do not work with primary cultures of neurons. Recent data, however, suggest that linear polymers of the cation…
Updated Oct 29, 2026
HealthData.Gov
Osteoclast activation is a critical cellular process for pathological bone resorption, such as erosions in rheumatoid arthritis (RA) or generalized bone loss. Among many factors triggering excessive osteoclast activity,…
Updated Oct 29, 2026
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Research Article: Current Controlled Trials in Cardiovascular Medicine
Updated Oct 29, 2026
HealthData.Gov
Background The "integrated safety report" of the drug registration files submitted to health authorities usually summarizes the rates of adverse events observed for a new drug, placebo or active control drugs by pooling…
Updated Oct 29, 2026
HealthData.Gov
Transgenic mice overexpressing IFN-γ in the epidermis develop an inflammatory skin disease resembling cutaneous lupus erythematosus shortly after birth. By 3 months of age, most female transgenics develop a lupus-like…
Updated Oct 29, 2026
HealthData.Gov
Background Although closely related, the alpha-proteobacteria Wolbachia and the Rickettsiacae (Rickettsia and Ehrlichia), employ different evolutionary life history strategies. Wolbachia are obligate endocellular…
Updated Oct 29, 2026
HealthData.Gov
Background The objective of the present study was to examine the prognostic and predictive significance of the apoptosis-related marker Fas ligand (FasL):Fas ratio in breast cancer. Methods Tumour biopsies from 215…
Updated Oct 29, 2026
HealthData.Gov
Background The purpose of this clinical study is to evaluate the feasibility of using 2-mm laparoscopic instruments to perform an appendectomy in patients with clinically suspected acute appendicitis and compare the…
Updated Oct 29, 2026
HealthData.Gov
Background Etoricoxib is a highly selective COX-2 inhibitor which was evaluated for the treatment of rheumatoid arthritis (RA). Methods Double-blind, randomized, placebo and active comparator-controlled, 12-week study…
Updated Oct 29, 2026
HealthData.Gov
Background Antioxidant supplementation with vitamin E had no effect in the prevention of cardiovascular diseases (CVD) in three recent large, randomized clinical trials. In order to reassess critically the role of…
Updated Oct 29, 2026
HealthData.Gov
Background Mortality rates in Western Europe have fallen significantly over the last 50 years. Maternal mortality now averages 10 maternal deaths per 100,000 live births but in some of the Newly Independent States of…
Updated Oct 29, 2026
HealthData.Gov
Background It is well established that ACE-inhibitors should be avoided in patients with renal artery stenosis. In recent years it has also been recommended that caution should be demonstrated when angiotensin II…
Updated Oct 29, 2026
HealthData.Gov
This case report describes removal of a knotted, subclavian, pulmonary artery catheter using a tracheostomy dilator. With this simple method an invasive procedure might be averted.
Updated Oct 29, 2026
HealthData.Gov
Background Using genetic distances measured from exons, it has been observed that the mutation rate is not constant along mammalian chromosomes. Exons constitute only 1% of the human genome, however, and thus they…
Updated Oct 29, 2026
HealthData.Gov
Background Bariatric patients showing poor "focus" during treatment more often failed to lose weight or maintain reduced weight. Evaluation of these patients identified a number having attention deficit/hyperactivity…
Updated Oct 29, 2026
HealthData.Gov
Background Iranian breast cancer patients are relatively younger than their Western counterparts. The objective of the present study was to investigate risk factors for breast cancer in Iranian women. Method A…
Updated Oct 29, 2026
HealthData.Gov
A heuristically modified version of fuzzy k-means clustering has been used to identify overlapping clusters of yeast genes based on published gene-expression data following the response of yeast cells to environmental…
Updated Oct 29, 2026
