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Introduction The purpose of the study was to validate the newly derived postoperative orthotopic liver transplantation (OLTX)-specific diagnostic weight for the Acute Physiology and Chronic Health Evaluation (APACHE) II…
Updated Oct 29, 2026
HealthData.Gov
Whether it matters how pressure is lowered has been debated since antihypertensive drugs proved to prevent cardiovascular events. However, in clinical trials, while the stroke benefit predicted by a given difference in…
Updated Oct 29, 2026
HealthData.Gov
Background Conserved domains in proteins have crucial roles in protein interactions, DNA binding, enzyme activity and other important cellular processes. It will be of interest to determine the proportions of genes…
Updated Oct 29, 2026
HealthData.Gov
This review focuses on the mechanisms of stress response in the synovial tissue of rheumatoid arthritis. The major stress factors, such as heat stress, shear stress, proinflammatory cytokines and oxidative stress, are…
Updated Oct 29, 2026
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The lack of efficient techniques for assessing the biological implications of microarray gene-expression data remains an important obstacle in exploiting this information. To address this need, a mining technique has…
Updated Oct 29, 2026
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Background Manipulation of the uterine epithelium utilising standard dose exogenous oestrogen (E2) and progesterone (P4) has been shown to achieve a mature secretory morphological response. However, in an in vitro…
Updated Oct 29, 2026
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Background People age at remarkably different rates, but how to estimate trajectories of senescence is controversial. Methods In a secondary analysis of a representative cohort of Canadians aged 65 and over (n = 2914)…
Updated Oct 29, 2026
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Background The timed-sequential chemotherapy regimen consisting of etoposide, mitoxantrone and cytarabine (EMA) is an effective therapy for relapsed or refractory acute myelogenous leukemia (AML). We postulated that…
Updated Oct 29, 2026
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Background GPIIb/IIIa inhibitors abciximab and eptifibatide have been shown to inhibit platelet aggregation in ischemic heart disease. Our aim was to test the efficacy of abiciximab (Reo Pro) or eptifibatide…
Updated Oct 29, 2026
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Background The loss of participants in longitudinal studies due to non-contact, refusal or death can introduce bias into the results of such studies. The study described here examines reasons for refusal over three…
Updated Oct 29, 2026
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This series of responses was commissioned to accompany the article by Singer et al, which can be found at . If you would like to comment on the article by Singer et al or any of the responses, please email us on…
Updated Oct 29, 2026
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Only a few randomized clinical trials have been performed so far in heart transplant recipients, mainly because of the relatively small number of heart transplants performed worldwide each year. The main focus of the…
Updated Oct 29, 2026
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Background The delta(δ)-opioid receptors belong to the G protein-coupled receptors and in vitro studies have shown that δ-opioid receptors undergo an internalization process in response to agonist stimulation. The…
Updated Oct 29, 2026
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Purpose The present study aimed at evaluating the efficacy of Raltitrexed, a specific thymidilate synthase inhibitor, in patients with advanced colorectal cancer (ACC) in relapse (>8 weeks) after a prior response or…
Updated Oct 29, 2026
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A common problem in clinical trials is the missing data that occurs when patients do not complete the study and drop out without further measurements. Missing data cause the usual statistical analysis of complete or all…
Updated Oct 29, 2026
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The observational studies of hormone users are compromised by systematic biases that lead to an overestimation of benefit and an underestimation of risk. Studies of mechanism could support either benefit or harm. The…
Updated Oct 29, 2026
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Background Recent work has suggested that the ovarian steroid 17β-estradiol, at physiological concentrations, may exert protective effects in neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease…
Updated Oct 29, 2026
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Introduction The aim of the current study was to assess the reliability, validity and psychometric properties of the Greek translation of the Center for Epidemiological Studies- Depression Scale (CES-D). Methods 40…
Updated Oct 29, 2026
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Several aspects of Journal of Biology seem to have caught readers' attention. Some of the questions asked have arisen sufficiently often to be worth addressing here.
Updated Oct 29, 2026
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Background T helper epitopes are necessary for the induction of high titers of antigen-specific IgG antibodies. We are interested in the epitope modification of intact proteins as a method to enhance their…
Updated Oct 29, 2026
