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There is mounting evidence indicating that the synovial fibroblast is a direct effector of tissue injury and matrix remodeling in inflammatory synovitis. Through the elaboration of effector signals including cytokines…
Updated Oct 29, 2026
HealthData.Gov
Background Very small genomes have evolved repeatedly in eubacterial lineages that have adopted obligate associations with eukaryotic hosts. Complete genome sequences have revealed that small genomes retain very…
Updated Oct 29, 2026
HealthData.Gov
Although mechanical ventilation is instituted as a life-saving technique, it may lead to complications that can negatively impact on patients' morbidity and/or mortality. Ventilator associated pneumonia (VAP) is one…
Updated Oct 29, 2026
HealthData.Gov
Background Norwalk virus causes outbreaks of acute non-bacterial gastroenteritis in humans. The virus capsid is composed of a single 60 kDa protein. In a previous study, the capsid protein of recombinant Norwalk virus…
Updated Oct 29, 2026
HealthData.Gov
Background Hep27 monoclonal (Hep27 Mab) is an antibody against hepatocellular carcinoma. Hep27 Mab itself can inhibit the growth of a hepatocellular carcinoma cell line (HCC-S102). We attempted to produce a single-chain…
Updated Oct 29, 2026
HealthData.Gov
Background The pathophysiology behind spina bifida and other neural tube defects (NTDs) is unclear. Folic acid is one variable, but other factors remain. Studies suggest that substances active at the GABA receptor may…
Updated Oct 29, 2026
HealthData.Gov
Objective To review published randomised controlled trials to assess the benefit and harm of imiquimod in the treatment of external genital warts. Data sources MEDLINE (1966 - December 2000), Cochrane Library (Issue 3,…
Updated Oct 29, 2026
HealthData.Gov
Background and Purpose It is not known whether carbamazepine (CBZ; a drug widely used in neurology and psychiatry) influences the blood oxygenation level dependent (BOLD) contrast changes induced by neuronal activation…
Updated Oct 29, 2026
HealthData.Gov
Objective To estimate the mortality and length of stay in the intensive care unit (ICU) attributable to clinically important gastrointestinal bleeding in mechanically ventilated critically ill patients. Design Three…
Updated Oct 29, 2026
HealthData.Gov
This review provides a detailed overview of the current state of knowledge about the ultrastructure and dynamics of liver sinusoidal endothelial fenestrae. Various aspects of liver sinusoidal endothelial fenestrae…
Updated Oct 29, 2026
HealthData.Gov
Paper reports overview: Restrictive transfusions, experienced radiologists and prone positioning
Updated Oct 29, 2026
HealthData.Gov
Background Hepatitis C is a serious problem on the Greek island of Crete, where a high prevalence of antibodies against hepatitis C (anti-HCV) has recently been reported. This article reports the findings of a study…
Updated Oct 29, 2026
HealthData.Gov
Background Iron deficiency (ID) results in ventricular hypertrophy, believed to involve sympathetic stimulation. We hypothesized that with ID 1) intravenous norepinephrine would alter heart rate (HR) and contractility,…
Updated Oct 29, 2026
HealthData.Gov
Activity of voltage-gated potassium (Kv) channels controls membrane potential, which subsequently regulates cytoplasmic free calcium concentration ([Ca2+]cyt) in pulmonary artery smooth muscle cells (PASMCs). Acute…
Updated Oct 29, 2026
HealthData.Gov
Background The failure mechanism of the knee ligament (bone-ligament-bone complex) at different strain rates is an important subject in the biomechanics of the knee. This study reviews and summarizes the literature…
Updated Oct 29, 2026
HealthData.Gov
Background One of the earliest steps in synaptogenesis at the neuromuscular junction is the aggregation of nicotinic acetylcholine receptors at the postsynaptic membrane. This study presents quantitative analyses of…
Updated Oct 29, 2026
HealthData.Gov
The causes of rheumatoid arthritis (RA) are largely unknown. However, RA is most probably a multifactorial disease with contributions from genetic and environmental factors. Searches for genes that influence RA have…
Updated Oct 29, 2026
HealthData.Gov
Background Prediction of protein structures is one of the fundamental challenges in biology today. To fully understand how well different prediction methods perform, it is necessary to use measures that evaluate their…
Updated Oct 29, 2026
HealthData.Gov
Background In computational analysis, the RING-finger domain is one of the most frequently detected domains in the Arabidopsis proteome. In fact, it is more abundant in Arabidopsis than in other eukaryotic genomes.…
Updated Oct 29, 2026
HealthData.Gov
Background Use of high daily doses of benzodiazepines is generally contraindicated for seniors. While both patient and physician factors may influence the use of high daily doses, previous research on the effect of…
Updated Oct 29, 2026
