Datasets

2,009 datasets

HealthData.Gov

Research Article: Current Controlled Trials in Cardiovascular Medicine

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Updated Oct 29, 2026

HealthData.Gov

Pooling, meta-analysis, and the evaluation of drug safety

Background The "integrated safety report" of the drug registration files submitted to health authorities usually summarizes the rates of adverse events observed for a new drug, placebo or active control drugs by pooling…

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Updated Oct 29, 2026

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IFN-gamma transgenic mice: clues to the pathogenesis of systemic lupus erythematosus?

Transgenic mice overexpressing IFN-γ in the epidermis develop an inflammatory skin disease resembling cutaneous lupus erythematosus shortly after birth. By 3 months of age, most female transgenics develop a lupus-like…

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Updated Oct 29, 2026

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Wolbachia: Evolutionary novelty in a rickettsial bacteria

Background Although closely related, the alpha-proteobacteria Wolbachia and the Rickettsiacae (Rickettsia and Ehrlichia), employ different evolutionary life history strategies. Wolbachia are obligate endocellular…

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Updated Oct 29, 2026

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Tumour Fas ligand:Fas ratio greater than 1 is an independent marker of relative resistance to tamoxifen therapy in hormone receptor positive breast cancer

Background The objective of the present study was to examine the prognostic and predictive significance of the apoptosis-related marker Fas ligand (FasL):Fas ratio in breast cancer. Methods Tumour biopsies from 215…

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Updated Oct 29, 2026

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Mini-laparoscopic versus laparoscopic approach to appendectomy

Background The purpose of this clinical study is to evaluate the feasibility of using 2-mm laparoscopic instruments to perform an appendectomy in patients with clinically suspected acute appendicitis and compare the…

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Updated Oct 29, 2026

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Commentary on "Genetic linkage and transmission disequilibrium of marker haplotypes at chromosome 1q41 in human systemic lupus erythematosus", by RR Graham

Genome-wide linkage analysis studies in families with systemic lupus erythematosus (SLE) have revealed consistent evidence of linkage to several regions of the genome. In a previous issue of this journal, Graham and…

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Updated Oct 29, 2026

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Crystal structure of murine sCEACAM1a[1,4]: a coronavirus receptor in the CEA family

CEACAM1 is a member of the carcinoembryonic antigen (CEA) family. Isoforms of murine CEACAM1 serve as receptors for mouse hepatitis virus (MHV), a murine coronavirus. Here we report the crystal structure of soluble…

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Updated Oct 29, 2026

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Do we need clinical trials to test the ability of transdermal HRT to prevent coronary heart disease?

Postmenopausal hormone replacement therapy (HRT) with oral oestrogen was predicted to reduce coronary heart disease (CHD) risk by 50%. Randomized controlled trials show no such benefit, however, pointing instead to an…

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Updated Oct 29, 2026

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Rational use of computerized protocols in the intensive care unit

Excess information in complex ICU environments exceeds human decision making limits, increasing the likelihood of clinical errors. Explicit decision-support tools have favorable effects on clinician and patient outcomes…

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Updated Oct 29, 2026

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A Review of the Adverse Effects of Peripheral Alpha-1 Antagonists in Hypertension Therapy

Background Doxazosin and its role as an antihypertensive agent have come under recent scrutiny as a result of the early termination of that treatment arm in ALLHAT. It is unclear why the cardiovascular (CV) event rate…

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Updated Oct 29, 2026

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Need for critical care in gynaecology: a population-based analysis

Introduction The purpose of this study was to note potential gynaecological risk factors leading to intensive care and to estimate the frequency, costs and outcome of management. Materials and methods In a…

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Updated Oct 29, 2026

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Comparative evaluation of gene delivery devices in primary cultures of rat hepatic stellate cells and rat myofibroblasts

Background The hepatic stellate cell is the primary cell type responsible for the excessive formation and deposition of connective tissue elements during the development of hepatic fibrosis in chronically injured liver.…

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Updated Oct 29, 2026

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Cell-cell interactions in synovitis: Endothelial cells and immune cell migration

Leukocyte ingress into the synovium is a key process in the pathogenesis of rheumatoid arthritis and other inflammatory conditions. In this review, the role of endothelial cells in leukocyte extravasation will be…

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Updated Oct 29, 2026

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The identity and distribution of neural cells expressing the mesodermal determinant

Background The spadetail (spt) gene of zebrafish is expressed in presomitic mesoderm and in neural cells previously suggested to be Rohon-Beard neurons. The mechanism(s) generating the apparently irregular rostrocaudal…

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Updated Oct 29, 2026

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Joint-specific and systemic autoreactivity in the development of inflammatory arthritis

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Updated Oct 29, 2026

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Prescribing patterns in premenstrual syndrome

Background Over 300 therapies have been proposed for premenstrual syndrome. To date there has been only one survey conducted in the UK of PMS treatments prescribed by GPs, a questionnaire-based study by the National…

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Updated Oct 29, 2026

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Expression profiles during honeybee caste determination

Background Depending on their larval environment, female honeybees develop into either queens or workers. As in other polyphenisms, this developmental switch depends not on genomic differences between queens and workers…

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Updated Oct 29, 2026

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Analysis of fluorescently labeled substance P analogs: binding, imaging and receptor activation

Background Substance P (SP) is a peptide neurotransmitter found in central and peripheral nerves. SP is involved in the control of smooth muscle, inflammation and nociception. The amino acid sequence of SP is…

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Updated Oct 29, 2026

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Clinical review: Immunodepression in the surgical patient and increased susceptibility to infection

Several studies indicate that organ failure is the leading cause of death in surgical patients. An excessive inflammatory response followed by a dramatic paralysis of cell-mediated immunity following major surgery…

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Updated Oct 29, 2026