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The tradition of circulating research findings before peerreview is old and continues today. In addition to the informal circulation of non-peer-reviewed research reports between scientists, there are also…
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The abdominal compartment syndrome represents the pathophysiologic consequence of a raised intra-abdominal pressure. Various clinical conditions are associated with this syndrome and include massive intra-abdominal or…
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Background Venous thromboembolism (VTE) confers considerable morbidity and mortality in hospitalized patients, although few studies have focused on the critically ill population. The objective of this study was to…
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Echocardiography: a fundamental part of the intensive care curriculum
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Objectives: To determine the degree of interinstitutional transfusion practice variation and reasons why red cells are administered in critically ill patients. Study design: Multicentre cohort study combined with a…
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As in other areas of medicine, the specialty of critical care medicine, which has made important contributions in the pathophysiology of critical illness, is facing challenges that must be recognized and addressed in…
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Many alarms, as they now exist in most monitoring systems, are not usually perceived as helpful by the medical staff because of the high incidence of false alarms. This paper gives an overview of the problems related to…
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The demand for intensive care has increased relentlessly over the past 30 years. It is now regarded as a necessity rather than a luxury. The provision of intensive care has lagged behind that demand. Thus, patients who…
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Recent evidence suggests that critically ill patients are able to tolerate lower levels of haemoglobin than was previously believed. It is our goal to show that transfusing to a level of 100 g/l does not improve…
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Objective: To evaluate the relationships between the changes in stroke volume index (SVI), measured in both the aorta and the pulmonary artery, and the changes in intrathoracic blood volume index (ITBVI), as well as the…
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Informed consent and research design in critical care medicine
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Objective To evaluate whether measurement of the hemoglobin (Hb) concentration with a blood gas analyzer approximates that determined by a conventional coulter counter in critically ill adults. Design Prospective…
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Our current state of knowledge on noninvasive positive pressure ventilation (NPPV) and technical aspects are discussed in the present review. In patients with chronic obstructive pulmonary disease, NPPV can be…
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Decision-making in the intensive care unit is often very difficult. Although we are encouraged to make evidence-based decisions, this may be difficult for a number of reasons. To begin with, evidence may not exist to…
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Pharmacology of the critically ill
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Agitation in the ICU: part one Anatomical and physiologic basis for the agitated state
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ICU resource allocation: life in the fast lane
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Blending science and compassion: The 30th educational symposium of the Society of Critical Care Medicine, San Francisco, USA, 10-14 February 2001
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The sound of silence: rationing resources for critically ill patients
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Background Lipopolysaccharide (endotoxin) from the cell wall of Gram-negative bacteria is a potent trigger for the release of host-derived inflammatory mediators. The relationship between endotoxaemia, Gram-negative…