A design prototype by Datopian, not an official website
Find a Commonwealth ResourceHealthData.Gov
Background Meta-analysis is often considered to be a simple way to summarize the existing literature. In this paper we describe how a meta-analysis resembles a conventional study, requiring a written protocol with…
Updated Oct 29, 2026
HealthData.Gov
The objective was to review the evidence of effectiveness of the polyvalent polysaccharide pneumococcal vaccine from prospective properly randomised controlled trials comparing pneumococcal vaccines with placebo in…
Updated Oct 29, 2026
HealthData.Gov
Background Calculation of numbers needed to treat (NNT) is more complex from meta-analysis than from single trials. Treating the data as if it all came from one trial may lead to misleading results when the trial arms…
Updated Oct 29, 2026
HealthData.Gov
Aims To examine the effect of updating a systematic review of nicotine replacement therapy on its contents and conclusions. Methods We examined the effects of regular updating of a systematic review of nicotine…
Updated Oct 29, 2026
HealthData.Gov
Background Although guidelines for critical appraisal of diagnostic research and meta-analyses have already been published, these may be difficult to understand for clinical researchers or do not provide enough detailed…
Updated Oct 29, 2026
HealthData.Gov
Background Gastric ulcers are a frequent problem in the United States. Proton pump inhibitors have been shown to increase healing rates and improve clinical symptoms. The objective of this study is to compare gastric…
Updated Oct 29, 2026
HealthData.Gov
Background A recent article in the New Scientist argued that women were under-represented in clinical trials which, until now, had masked the finding that ibuprofen 400 mg was ineffective in women. Methods Meta-analysis…
Updated Oct 29, 2026
HealthData.Gov
Background There are a variety of ways in which accuracy of clinical tests can be summarised in systematic reviews. Variation in reporting of summary measures has only been assessed in a small survey restricted to…
Updated Oct 29, 2026
HealthData.Gov
Background Hormone replacement therapy (HRT) is often seen as the treatment of choice for preventing fractures in women. We undertook a recent meta-analysis of randomised trials which suggested that HRT reduced…
Updated Oct 29, 2026
HealthData.Gov
Background Evaluation of company clinical trial reports could provide information for meta-analysis at the commercial introduction of a new technology. Methods Clinical trial reports of sildenafil for erectile…
Updated Oct 29, 2026
HealthData.Gov
Background The "integrated safety report" of the drug registration files submitted to health authorities usually summarizes the rates of adverse events observed for a new drug, placebo or active control drugs by pooling…
Updated Oct 29, 2026
HealthData.Gov
Background Meta-analysis usually restricts the information pooled, for instance using only randomised, double-blind, placebo-controlled trials. This neglects other types of high quality information. This review explores…
Updated Oct 29, 2026
