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Background The application of physiologically based pharmacokinetic models (PBPK) to human studies has been limited by the lack of the detailed organ information that is required for this analysis. PKQuest is a new…
Updated Oct 29, 2026
HealthData.Gov
Background This paper assess the relationship between the quantity of three anti-seizure medications in hair and the color of the analyzed hair, while controlling for the effects of dose, dose duration, and patient age…
Updated Oct 29, 2026
HealthData.Gov
Background It is generally assumed that the tissue exchange of antibiotics is flow limited (complete equilibration between the capillary and the tissue water). This assumption may not be valid if there is a large amount…
Updated Oct 29, 2026
HealthData.Gov
Background A "physiologically based pharmacokinetic" (PBPK) approach uses a realistic model of the animal to describe the pharmacokinetics. Previous PBPKs have been designed for specific solutes, required specification…
Updated Oct 29, 2026
HealthData.Gov
Pharmacology of the critically ill
Updated Oct 29, 2026
