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Background It is known that use of hormone replacement therapy (HRT) by postmenopausal women increases the risk of breast cancer. Method In this study, oestrogen receptor (ER)-α expression is examined using standard…
Updated Oct 29, 2026
HealthData.Gov
Large numbers of observational studies have described a decrease in the incidence of cardiovascular disease in women taking hormone replacement therapy (HRT). The potential mechanisms for this effect are numerous,…
Updated Oct 29, 2026
HealthData.Gov
Background Little empirical research has examined the multiple consequences of osteoporosis on quality of life. Methods Health related quality of life (HRQL) was examined in relationship to incident fractures in 2009…
Updated Oct 29, 2026
HealthData.Gov
The observational studies of hormone users are compromised by systematic biases that lead to an overestimation of benefit and an underestimation of risk. Studies of mechanism could support either benefit or harm. The…
Updated Oct 29, 2026
HealthData.Gov
Postmenopausal hormone replacement therapy (HRT) with oral oestrogen was predicted to reduce coronary heart disease (CHD) risk by 50%. Randomized controlled trials show no such benefit, however, pointing instead to an…
Updated Oct 29, 2026
