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HealthData.Gov

Statistical issues in randomized trials of cancer screening

Background The evaluation of randomized trials for cancer screening involves special statistical considerations not found in therapeutic trials. Although some of these issues have been discussed previously, we present…

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Updated Oct 29, 2026

HealthData.Gov

Bridging case-control studies and randomized trials

Randomized trials and observational studies, such as case-control studies, are often seen as opposing approaches. However, in many instances results obtained by different designs may complement each other. For instance,…

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Updated Oct 29, 2026