Datasets

2 datasets

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HealthData.Gov

Reduced natriuretic response to acute sodium loading in COMT Gene deleted mice

Background The intrarenal natriuretic hormone dopamine (DA) is metabolised by catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO). Inhibition of COMT, as opposed to MAO, results in a potent natriuretic…

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Updated Oct 29, 2026

HealthData.Gov

Omapatrilat normalizes renal function curve in spontaneously hypertensive rats

Background The present study was designed to analyze the chronic renal response to omapatrilat, a new vasopeptidase inhibitor, in spontaneously hypertensive rats (SHR). To that end, the renal and blood pressure response…

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Updated Oct 29, 2026