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Background There is debate concerning methods for calculating numbers needed to treat (NNT) from results of systematic reviews. Methods We investigate the susceptibility to bias for alternative methods for calculating…
Updated Oct 29, 2026
HealthData.Gov
Background The "integrated safety report" of the drug registration files submitted to health authorities usually summarizes the rates of adverse events observed for a new drug, placebo or active control drugs by pooling…
Updated Oct 29, 2026
HealthData.Gov
Background Calculation of numbers needed to treat (NNT) is more complex from meta-analysis than from single trials. Treating the data as if it all came from one trial may lead to misleading results when the trial arms…
Updated Oct 29, 2026
