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HealthData.Gov

Debate: Subgroup analyses in clinical trials: fun to look at - but don't believe them!

Analysis of subgroup results in a clinical trial is surprisingly unreliable, even in a large trial. This is the result of a combination of reduced statistical power, increased variance and the play of chance. Reliance…

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Updated Oct 29, 2026

HealthData.Gov

How many replicates of arrays are required to detect gene expression changes in microarray experiments? A mixture model approach

Background It has been recognized that replicates of arrays (or spots) may be necessary for reliably detecting differentially expressed genes in microarray experiments. However, the often-asked question of how many…

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Updated Oct 29, 2026

HealthData.Gov

The use of percentage change from baseline as an outcome in a controlled trial is statistically inefficient: a simulation study

Background Many randomized trials involve measuring a continuous outcome - such as pain, body weight or blood pressure - at baseline and after treatment. In this paper, I compare four possibilities for how such trials…

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Updated Oct 29, 2026

HealthData.Gov

Prominent medical journals often provide insufficient information to assess the validity of studies with negative results

Background Physicians reading the medical literature attempt to determine whether research studies are valid. However, articles with negative results may not provide sufficient information to allow physicians to…

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Updated Oct 29, 2026