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HealthData.Gov

The International Sepsis Forum's controversies in sepsis: corticosteroids should not be routinely used to treat septic shock

Corticosteroid treatment of severe sepsis has been one of the most controversial clinical issues in critical care. In fact, few agents can claim to have been evaluated in scores of studies spanning 3–4 decades. Yet,…

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Updated Oct 29, 2026

HealthData.Gov

Decreased levels of dehydroepiandrosterone sulphate in severe critical illness: a sign of exhausted adrenal reserve?

Introduction Dehydroepiandrosterone (DHEA) and its sulphate (DHEAS) are pleiotropic adrenal hormones with immunostimulating and antiglucocorticoid effects. The present study was conducted to evaluate the time course of…

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Updated Oct 29, 2026

HealthData.Gov

The International Sepsis Forum's controversies in sepsis: corticosteroids should be used to treat septic shock

The use of corticosteroids in septic shock remains controversial. It has been demonstrated that high doses of steroids (30 mg/kg methylprednisolone) for short periods of time are not beneficial. More recent studies…

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Updated Oct 29, 2026