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The fundamental methodological deficiency of megatrials is deliberate reduction of experimental control in order to maximize recruitment and compliance of subjects. Hence, typical megatrials recruit pathologically and…
Updated Oct 29, 2026
HealthData.Gov
The results and interpretations of the most recent controlled clinical trials on antihypertensive drugs have fuelled the debate about the drug that should be used to begin treatment for hypertension. Every comparison of…
Updated Oct 29, 2026
HealthData.Gov
Background The aim of this study was to examine the determinants of publication and whether publication bias occurred in gastroenterological research. Methods A random sample of abstracts submitted to DDW, the major GI…
Updated Oct 29, 2026
HealthData.Gov
Background Acceptability curves have been proposed for quantifying the probability that a treatment under investigation in a clinical trial is cost-effective. Various definitions and estimation methods have been…
Updated Oct 29, 2026
HealthData.Gov
Background Readers may question the interpretation of findings in clinical trials when multiple outcome measures are used without adjustment of the p-value. This question arises because of the increased risk of Type I…
Updated Oct 29, 2026
HealthData.Gov
Analysis of subgroup results in a clinical trial is surprisingly unreliable, even in a large trial. This is the result of a combination of reduced statistical power, increased variance and the play of chance. Reliance…
Updated Oct 29, 2026
HealthData.Gov
In light of the slow progress in developing effective therapies for ischemic stroke, magnetic resonance imaging techniques have emerged as new tools in stroke clinical trials. Rapid imaging with magnetic resonance…
Updated Oct 29, 2026
HealthData.Gov
Are there fundamental deficiencies in the megatrial methodology?
Updated Oct 29, 2026
HealthData.Gov
The publication of the results of the Swedish Trial in Old Patients with Hypertension-2 (STOP-2) and the termination of the doxazocin arm of the Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack…
Updated Oct 29, 2026
HealthData.Gov
An explanation for the higher incidence of cardiovascular disease and heart failure in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) with doxazosin and the Vasodilator Heart…
Updated Oct 29, 2026
HealthData.Gov
The recent scientific session of the American College of Cardiology (ACC), held in Orlando, provided a forum for ongoing cardiovascular clinical trials from around the world. The high point was clearly the first ever…
Updated Oct 29, 2026
HealthData.Gov
Background Complementary therapies are widespread but controversial. We aim to provide a comprehensive collection and a summary of systematic reviews of clinical trials in three major complementary therapies…
Updated Oct 29, 2026
HealthData.Gov
Background We examined whether quarterly patient enrollment in a large multicenter clinical trials group could be modeled in terms of predictors including time parameters (such as long-term trends and seasonality), the…
Updated Oct 29, 2026
HealthData.Gov
Clinical trialists and statisticians are very wary of subgroup analysis, for good reasons. Clinicians have to deal with situations in which subgroups of patients differ widely from one another in their prognosis and…
Updated Oct 29, 2026
HealthData.Gov
Three clinical trials have recently focused on the benefits of lipid-regulating therapy in populations with normocholesterolaemia and low high-density lipoprotein (HDL)-cholesterol. Two secondary prevention studies…
Updated Oct 29, 2026
HealthData.Gov
Only a few randomized clinical trials have been performed so far in heart transplant recipients, mainly because of the relatively small number of heart transplants performed worldwide each year. The main focus of the…
Updated Oct 29, 2026
HealthData.Gov
A common problem in clinical trials is the missing data that occurs when patients do not complete the study and drop out without further measurements. Missing data cause the usual statistical analysis of complete or all…
Updated Oct 29, 2026
HealthData.Gov
This symposium provided a useful forum for the discussion of issues relating to the design and conduct of clinical trials. There is a need for greater awareness of the complexity of modern day trials, in which a host of…
Updated Oct 29, 2026
HealthData.Gov
Background Evaluation of company clinical trial reports could provide information for meta-analysis at the commercial introduction of a new technology. Methods Clinical trial reports of sildenafil for erectile…
Updated Oct 29, 2026
HealthData.Gov
Research Article: Current Controlled Trials in Cardiovascular Medicine
Updated Oct 29, 2026
