Datasets

3 datasets

HealthData.Gov

Retrovirus-delivered siRNA

The ability of transfected synthetic small interfering (si) RNAs to suppress the expression of specific transcripts has proved a useful technique to probe gene function in mammalian cells. However, high production costs…

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Updated Oct 29, 2026

HealthData.Gov

Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in

RNAi can be achieved by feeding worms Escherichia coli expressing dousble-stranded RNA corresponding to a specific gene. An optimized feeding method is presented that results in phenotypes at least as strong as those…

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Updated Oct 29, 2026

HealthData.Gov

Phenotypic silencing of cytoplasmic genes using sequence-specific double-stranded short interfering RNA and its application in the reverse genetics of wild type negative-strand RNA viruses

Background Post-transcriptional gene silencing (PTGS) by short interfering RNA has opened up new directions in the phenotypic mutation of cellular genes. However, its efficacy on non-nuclear genes and its effect on the…

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Updated Oct 29, 2026