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WhenArthritis Researchwas launched in 1999 the publishers and ourselves took the innovative decision to make all primary research articles available to everyone for free through the journal's own…
Updated Oct 29, 2026
HealthData.Gov
It is a rare treat when a drug discovery program teaches us something about the biology of the process that it attempts to modulate. The paper by Maria Frank-Kamenetsky and colleagues in this issue of theJournal of…
Updated Oct 29, 2026
HealthData.Gov
Although various endothelium-dependent relaxing factors (endothelial autacoids) are released upon the elevation of endothelial cytosolic free Ca2+concentration (EC [Ca2+]i), the quantitative relationship between EC…
Updated Oct 29, 2026
HealthData.Gov
AllChlamydiaspecies are obligate intracellular bacterial parasites, and all are pathogenic to their various hosts [1].Chlamydia trachomatisandChlamydia pneumoniaeare human pathogens; the former being the etiologic agent…
Updated Oct 29, 2026
HealthData.Gov
The number of Nudix hydrolase family members varies widely among different organisms. In order to understand the reasons for the particular spectrum possessed by a given organism, the substrate specificity and function…
Updated Oct 29, 2026
HealthData.Gov
We are delighted to welcome you to the first printed issue ofArthritis Research, a publication that has already existed on the Internet for the last few months. This fact alone is an indication that we are beginning a…
Updated Oct 29, 2026
HealthData.Gov
The Mitotic Exit Network (MEN) proteins – including the protein kinase Cdc15 and the protein phosphatase Cdc14 – are essential for exit from mitosis inSaccharomyces cerevisiae.To identify downstream targets of the MEN,…
Updated Oct 29, 2026
HealthData.Gov
Amyotrophic lateral sclerosis (ALS) is a progressive lethal disorder of large motor neurons of the spinal cord and brain. In approximately 20% of the familial and 2% of sporadic cases the disease is due to a defect in…
Updated Oct 29, 2026
HealthData.Gov
Previous studies have shown that several agents that stimulate heptahelical G-protein coupled receptors activate the extracellular signal regulated kinases ERK1 (p44mapk) and ERK2 (p42mapk) in hepatocytes. The molecular…
Updated Oct 29, 2026
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Germline mutations in the tumor suppressorPTENpredispose human beings to breast cancer, and genetic and epigenetic alterations ofPTENare also detected in sporadic human breast cancer. GermlinePtenmutations in mice lead…
Updated Oct 29, 2026
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Macrophages, osteoclasts, dendritic cells, and microglia are highly specialized cells that belong to the mononuclear phagocyte system. Functional and phenotypic heterogeneity within the mononuclear phagocyte system may…
Updated Oct 29, 2026
HealthData.Gov
In this issue of the journal, Steinwaldet al[1] extend limited clinical studies and report an animal experiment showing that calcitonin precursors (predominantly procal-citonin) are elevated in proportion to the…
Updated Oct 29, 2026
HealthData.Gov
This year marks the 100th anniversary of the discovery by Camillo Golgi of an “internal reticular apparatus” in eukaryotic cells. The cover figure, from a classic paper by Friend and Murray (Friend, D.S., and Murray,…
Updated Oct 29, 2026
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The tradition of circulating research findings before peerreview is old and continues today. In addition to the informal circulation of non-peer-reviewed research reports between scientists, there are also…
Updated Oct 29, 2026
HealthData.Gov
SinceMycobacterium aviumsubspeciesparatuberculosis(MAP) was isolated from intestinal tissue of a human patient suffering Crohn's disease, a controversial discussion exists whether MAP have a role in the etiology of…
Updated Oct 29, 2026
HealthData.Gov
ManyHelicobacter pylorieradication regimens have been described. There are little data reporting their efficacy or integration in routine clinical practice. The overall results of eradication therapy in a cohort of…
Updated Oct 29, 2026
HealthData.Gov
The adaptor protein p130Cas(Cas) has been shown to be involved in different cellular processes including cell adhesion, migration and transformation. This protein has a substrate domain with up to 15 tyrosines that are…
Updated Oct 29, 2026
HealthData.Gov
Blood substitutes have long been sought after, and artificial oxygen carriers may soon become a reality. Despite increased safety of allogeneic blood in terms of transmission of infectious diseases [1], avoiding…
Updated Oct 29, 2026
HealthData.Gov
Percutaneous tracheostomy (PT) has gained an increasing acceptance as an alternative to the conventional surgical tracheostomy (ST). In experienced hands, and with proper patient selection, it is safe, easy and quick.
Updated Oct 29, 2026
HealthData.Gov
The abdominal compartment syndrome represents the pathophysiologic consequence of a raised intra-abdominal pressure. Various clinical conditions are associated with this syndrome and include massive intra-abdominal or…
Updated Oct 29, 2026
