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Articular cartilage has limited capacity to repair. Defects greater than 3 mm heal with formation of inferior fibrous cartilage. Therefore, many attempts have been made to find the ideal graft for larger cartilage…
Updated Oct 29, 2026
HealthData.Gov
Immotile cilia syndrome (ICS) or primary ciliary dyskinesia (PCD) is an autosomal recessive disorder in humans in which the beating of cilia and sperm flagella is impaired. Ciliated epithelial cell linings are present…
Updated Oct 29, 2026
HealthData.Gov
The synovium lines the noncartilaginous surfaces of the diarthrodial joints, and synovial tissue is also found in tendon sheaths and bursae [1]. Several rheumatic diseases are characterized by synovial inflammation. In…
Updated Oct 29, 2026
HealthData.Gov
The association ofChlamydia pneumoniaewith atherosclerosis is controversial. We investigated the presence ofC. pneumoniaeand otherChlamydiaspp. in atheromatous carotid artery tissue.
Updated Oct 29, 2026
HealthData.Gov
Tumor Necrosis Factor-α (TNF-α) has been implicated in the pathogenesis of insulin resistance and obesity. The increased expression of TNF-α in adipose tissue has been shown to induce insulin resistance, and a…
Updated Oct 29, 2026
HealthData.Gov
Spontaneous premature ovarian failure presents most commonly with secondary amenorrhea. Young women with the disorder are infertile and experience the symptoms and sequelae of estrogen deficiency. The mechanisms that…
Updated Oct 29, 2026
HealthData.Gov
Mycobacterium aviumsubspeciesparatuberculosis(M. paratuberculosis) is a facultative intracellular pathogen that resides within host macrophages during infection of ruminant animals. We examined survival ofM.…
Updated Oct 29, 2026
HealthData.Gov
Early diagnosis of wound colonisation or prediction of wound sepsis provides an opportunity for therapeutic intervention. There is need for qualitative and quantitative tests that are more rapid than bacterial…
Updated Oct 29, 2026
HealthData.Gov
From its origins in the 16thcentury, microscopy has allowed the cell, as the basic unit of eukaryotic life and disease, to be identified and analyzed. Today, quantitative cytometric technologies, either microscope based…
Updated Oct 29, 2026
HealthData.Gov
I am delighted to welcome you to the first printed issue ofRespiratory Research. This new journal, available both on the World Wide Web and in print, will provide timely reviews and rapid publication of primary research…
Updated Oct 29, 2026
HealthData.Gov
Cytokines play a critical role in regulating lymphoid cell responses to most antigenic stimuli, and it is therefore very likely that these molecules profoundly affect the pathogenesis of autoimmune diseases.…
Updated Oct 29, 2026
HealthData.Gov
The ability of transfected synthetic small interfering (si) RNAs to suppress the expression of specific transcripts has proved a useful technique to probe gene function in mammalian cells. However, high production costs…
Updated Oct 29, 2026
HealthData.Gov
WhenArthritis Researchwas launched in 1999 the publishers and ourselves took the innovative decision to make all primary research articles available to everyone for free through the journal's own…
Updated Oct 29, 2026
HealthData.Gov
Although various endothelium-dependent relaxing factors (endothelial autacoids) are released upon the elevation of endothelial cytosolic free Ca2+concentration (EC [Ca2+]i), the quantitative relationship between EC…
Updated Oct 29, 2026
HealthData.Gov
AllChlamydiaspecies are obligate intracellular bacterial parasites, and all are pathogenic to their various hosts [1].Chlamydia trachomatisandChlamydia pneumoniaeare human pathogens; the former being the etiologic agent…
Updated Oct 29, 2026
HealthData.Gov
The number of Nudix hydrolase family members varies widely among different organisms. In order to understand the reasons for the particular spectrum possessed by a given organism, the substrate specificity and function…
Updated Oct 29, 2026
HealthData.Gov
The Mitotic Exit Network (MEN) proteins – including the protein kinase Cdc15 and the protein phosphatase Cdc14 – are essential for exit from mitosis inSaccharomyces cerevisiae.To identify downstream targets of the MEN,…
Updated Oct 29, 2026
HealthData.Gov
Amyotrophic lateral sclerosis (ALS) is a progressive lethal disorder of large motor neurons of the spinal cord and brain. In approximately 20% of the familial and 2% of sporadic cases the disease is due to a defect in…
Updated Oct 29, 2026
HealthData.Gov
Previous studies have shown that several agents that stimulate heptahelical G-protein coupled receptors activate the extracellular signal regulated kinases ERK1 (p44mapk) and ERK2 (p42mapk) in hepatocytes. The molecular…
Updated Oct 29, 2026
HealthData.Gov
Germline mutations in the tumor suppressorPTENpredispose human beings to breast cancer, and genetic and epigenetic alterations ofPTENare also detected in sporadic human breast cancer. GermlinePtenmutations in mice lead…
Updated Oct 29, 2026
